Syk ELISA Kit for Mouse(Mus musculus) | EIAab.comSyk ELISA Kit for Mouse(Mus musculus)

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Syk (Gene name),

Tyrosine-protein kinase SYK (Protein name ), KSYK_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Syk(Sykb;Sykb);

Protein name:

Tyrosine-protein kinase SYK;

Alternative:

Spleen tyrosine kinase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with YWHAG/1433-gamma, which attenuates BCR-induced membrane translocation and activation (By similarity). Interacts (phosphorylated form) with SLA; the interaction may link it to CBL, leading to its destruction. Interacts with FCRL3. Interacts (via the second SH2 domain) with USP25 (via C-terminus) (By similarity). Interacts with RHOH, GAB2 and with NFAM1 (phosphorylated form). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation. Interacts with ITGB2 and FGR.

Function:

Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Likewise, mediates responses to ITGB2 signaling and plays an important role in the regulation of down-stream signaling cascades. Phosphorylates USP25 and regulates its intracellular levels.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

629

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

629:

LCWTYDVENR | PGFTAVELRL | RNYYYDVVN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P48025

Pfam:

PF07714

SMR:

P48025

KEGG:

mmu:20963

UniGene:

Mm.375031

Uniprot:

P48025

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ELISA Kit for Mouse Tyrosine-protein kinase SYK

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E1520r

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ELISA Kit for Mouse Tyrosine-protein kinase SYK

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E1520h

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96T

ELISA Kit for Mouse Tyrosine-protein kinase SYK

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E1520c

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96T

ELISA Kit for Mouse Tyrosine-protein kinase SYK

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E1520m

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ELISA Kit for Mouse Tyrosine-protein kinase SYK

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E1520p

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96T

CLIA Kit for Mouse Tyrosine-protein kinase SYK

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U1520m

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96T

CLIA Kit for Mouse Tyrosine-protein kinase SYK

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U1520r

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96T

CLIA Kit for Mouse Tyrosine-protein kinase SYK

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U1520c

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96T

CLIA Kit for Mouse Tyrosine-protein kinase SYK

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U1520h

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96T

CLIA Kit for Mouse Tyrosine-protein kinase SYK

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U1520p

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Polyclonal Antibody for Mouse Tyrosine-protein kinase SYK

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P1520Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Tyrosine-protein kinase SYK

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P1520Rb-m

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Polyclonal Antibody for Mouse Tyrosine-protein kinase SYK

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P1520Rb-r

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Polyclonal Antibody for Mouse Tyrosine-protein kinase SYK

Monoclonal Antibody for Mouse Tyrosine-protein kinase SYK

Protein for Mouse Tyrosine-protein kinase SYK

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk."
Turner M. , Mee P.J. , Costello P.S. , Williams O. , Price A.A. , Duddy L.P. , Furlong M.T. , Geahlen R.L. , Tybulewicz V.L.
Nature378:298-302(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DISRUPTION PHENOTYPE
2.

"Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein."
Flueck M. , Zuercher G. , Andres A. , Ziemiecki A.
Biochem. Biophys. Res. Commun.213:273-281(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Spleen.
3.

Richards J.D. , Gold M.R. , Hourihane S.L. , Defranco A.L. , Matsuuchi L.
Submitted (1995-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling."
Kurosaki T. , Takata M. , Yamanashi Y. , Inazu T. , Taniguchi T. , Yamamoto T. , Yamamura H.
J. Exp. Med.179:1725-1729(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY LYN
5.

"Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation."
Rowley R.B. , Burkhardt A.L. , Chao H.-G. , Matsueda G.R. , Bolen J.B.
J. Biol. Chem.270:11590-11594(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD79A
6.

"Syk tyrosine kinase required for mouse viability and B-cell development."
Cheng A.M. , Rowley B. , Pao W. , Hayday A. , Bolen J.B. , Pawson T.
Nature378:303-306(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
7.

"The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen."
Poole A. , Gibbins J.M. , Turner M. , van Vugt M.J. , van de Winkel J.G. , Saito T. , Tybulewicz V.L. , Watson S.P.
EMBO J.16:2333-2341(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF PLATELETS BY COLLAGEN;FUNCTION IN PLCG2 PHOSPHORYLATION
8.

"Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr."
Vines C.M. , Potter J.W. , Xu Y. , Geahlen R.L. , Costello P.S. , Tybulewicz V.L. , Lowell C.A. , Chang P.W. , Gresham H.D. , Willman C.L.
Immunity15:507-519(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTEGRIN SIGNALING;PHOSPHORYLATION AT TYR-342; TYR-519 AND TYR-520;INTERACTION WITH ITGB2 AND FGR
9.

"Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase."
Hong J.J. , Yankee T.M. , Harrison M.L. , Geahlen R.L.
J. Biol. Chem.277:31703-31714(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-317; TYR-342 AND TYR-346
10.

"Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton."
Obergfell A. , Eto K. , Mocsai A. , Buensuceso C. , Moores S.L. , Brugge J.S. , Lowell C.A. , Shattil S.J.
J. Cell Biol.157:265-275(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTEGRIN-MEDIATED PLATELET ADHESION
11.

"Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk."
Sohn H.W. , Gu H. , Pierce S.K.
J. Exp. Med.197:1511-1524(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY CBLB;ENZYME REGULATION
12.

"Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk."
Abtahian F. , Guerriero A. , Sebzda E. , Lu M.M. , Zhou R. , Mocsai A. , Myers E.E. , Huang B. , Jackson D.G. , Ferrari V.A. , Tybulewicz V. , Lowell C.A. , Lepore J.J. , Koretzky G.A. , Kahn M.L.
Science299:247-251(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VASCULAR DEVELOPMENT
13.

"NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling."
Ohtsuka M. , Arase H. , Takeuchi A. , Yamasaki S. , Shiina R. , Suenaga T. , Sakurai D. , Yokosuka T. , Arase N. , Iwashima M. , Kitamura T. , Moriya H. , Saito T.
Proc. Natl. Acad. Sci. U.S.A.101:8126-8131(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFAM1
14.

"Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production."
Underhill D.M. , Rossnagle E. , Lowell C.A. , Simmons R.M.
Blood106:2543-2550(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ROS PRODUCTION;FUNCTION IN RESPONSE TO FUNGAL PATHOGEN
15.

"Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins."
Rogers N.C. , Slack E.C. , Edwards A.D. , Nolte M.A. , Schulz O. , Schweighoffer E. , Williams D.L. , Gordon S. , Tybulewicz V.L. , Brown G.D. , Reis e Sousa C.
Immunity22:507-517(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RESPONSE TO FUNGAL PATHOGEN;INTERACTION WITH CLEC7A;SUBCELLULAR LOCATION
16.

"A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2."
Suzuki-Inoue K. , Fuller G.L.J. , Garcia A. , Eble J.A. , Poehlmann S. , Inoue O. , Gartner T.K. , Hughan S.C. , Pearce A.C. , Laing G.D. , Theakston R.D.G. , Schweighoffer E. , Zitzmann N. , Morita T. , Tybulewicz V.L.J. , Ozaki Y. , Watson S.P.
Blood107:542-549(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF PLATELETS BY CLEC1B
17.

"Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI."
Yu M. , Lowell C.A. , Neel B.G. , Gu H.
J. Immunol.176:2421-2429(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GAB2
18.

"Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs."
Mocsai A. , Abram C.L. , Jakus Z. , Hu Y. , Lanier L.L. , Lowell C.A.
Nat. Immunol.7:1326-1333(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTEGRIN-MEDIATED NEUTROPHIL ACTIVATION;INTERACTION WITH FCER1G AND TYROBP;MUTAGENESIS OF ARG-41 AND ARG-194
19.

"Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption."
Zou W. , Kitaura H. , Reeve J. , Long F. , Tybulewicz V.L. , Shattil S.J. , Ginsberg M.H. , Ross F.P. , Teitelbaum S.L.
J. Cell Biol.176:877-888(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN OSTEOCLASTIC BONE RESORPTION
20.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310; SER-313; TYR-317; TYR-342; TYR-346; TYR-519; TYR-520; TYR-540; TYR-623 AND TYR-624;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
21.

"The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development."
Kulathu Y. , Hobeika E. , Turchinovich G. , Reth M.
EMBO J.27:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BLNK
22.

"Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection."
Van Ziffle J.A. , Lowell C.A.
Blood114:4871-4882(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RESPONSE TO BACTERIA
23.

"RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells."
Oda H. , Fujimoto M. , Patrick M.S. , Chida D. , Sato Y. , Azuma Y. , Aoki H. , Abe T. , Suzuki H. , Shirai M.
J. Immunol.182:957-962(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MAST CELL ACTIVATION;INTERACTION WITH RHOH;ENZYME REGULATION
24.

"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence."
Gross O. , Poeck H. , Bscheider M. , Dostert C. , Hannesschlaeger N. , Endres S. , Hartmann G. , Tardivel A. , Schweighoffer E. , Tybulewicz V. , Mocsai A. , Tschopp J. , Ruland J.
Nature459:433-436(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RESPONSE TO FUNGAL PATHOGEN;FUNCTION IN INFLAMMASOME ACTIVATION;FUNCTION IN REGULATION OF TRANSCRIPTION
25.

"Identification of a dendritic cell receptor that couples sensing of necrosis to immunity."
Sancho D. , Joffre O.P. , Keller A.M. , Rogers N.C. , Martinez D. , Hernanz-Falcon P. , Rosewell I. , Reis e Sousa C.
Nature458:899-903(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IMMUNE SYSTEM STIMULATION BY CELL NECROSIS

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